Saffitz, M.D., Ph.D.: A New Diagnostic Check for Arrhythmogenic Best Ventricular Cardiomyopathy Arrhythmogenic correct ventricular cardiomyopathy is definitely associated with a high frequency of arrhythmias and unexpected cardiac death.1-3 Mutations in genes encoding desmosomal proteins have been identified in approximately 40 percent of individuals with ARVC.4 However, genetic analysis continues to be a research tool, and in everyday practice, the medical diagnosis of ARVC can be challenging. The clinical display may be highly variable, and the genetic penetrance is often low. This is also true in family of an index individual in whom establishing a analysis of ARVC requires considerable clinical workup, often leading to equivocal results. Endomyocardial biopsy has not been consistently useful because the structural changes in ARVC tend to extra the subendocardium , nor typically involve the interventricular septum.2 Thus, the pathological features of ARVC are not seen in conventional endomyocardial-biopsy specimens often.The tender present statement and the solicitation/suggestion statement contain important info that should be read cautiously and regarded before any decision is made with regards to the tender give. Additionally, Durata andActavishave filed and may later on file other relevant components regarding the the proposed acquisition of Durata byActavispursuant to the terms of the merger agreement. In addition, most of these materials will be accessible at no charge from theSecurities and Exchange Commissionthrough its website at Free copies of the offer to purchase, the related letter of transmittal and particular other offering documents may be attained by directing a demand toActavis'Investor Relations Department at 261-7488.