The specific role this protein plays in the advancement of ankylosing spondylitis is definitely unclear.. AS Orthopedic Causes The exact cause of ankylosing spondylitis remains unknown. A possible genetic link exists, as the risk of developing ankylosing spondylitis or any other seronegative spondyloarthropathy increases when a family member gets the condition. Ankylosing spondylitis and the additional spondyloarthropathies have already been linked to a particular protein also, HLA-B27, in someone’s blood.This trial was performed at three centers comprising 35 sites in Jiangsu Province, China. The trial process and the informed-consent form were authorized by the ethics committee of the JSCDC. Before enrollment, written informed consent was obtained from a guardian or mother or father of each participant. The trial was carried out relative to the concepts of the Declaration of Helsinki, the criteria of Great Clinical Practice , and Chinese regulatory requirements.