AS Orthopedic Causes The exact cause of ankylosing spondylitis remains unknown.

The specific role this protein plays in the advancement of ankylosing spondylitis is definitely unclear.. AS Orthopedic Causes The exact cause of ankylosing spondylitis remains unknown. A possible genetic link exists, as the risk of developing ankylosing spondylitis or any other seronegative spondyloarthropathy increases when a family member gets the condition. Ankylosing spondylitis and the additional spondyloarthropathies have already been linked to a particular protein also, HLA-B27, in someone’s blood.This trial was performed at three centers comprising 35 sites in Jiangsu Province, China. The trial process and the informed-consent form were authorized by the ethics committee of the JSCDC. Before enrollment, written informed consent was obtained from a guardian or mother or father of each participant. The trial was carried out relative to the concepts of the Declaration of Helsinki, the criteria of Great Clinical Practice , and Chinese regulatory requirements.