CORIN variants have been associated with center and hypertension disease in African Americans.

An alternative initiation site, Met-30, can be indicated by an arrowhead.Full size imageThe variant allele occurred more frequently in hypertensive patients than normal individuals. In the first research cohort, 23 of 401 hypertensive patients were heterozygous for this variant allele, whereas 2 of 217 normal individuals were heterozygous for the variant allele . We verified this finding in another study cohort. Among 394 hypertensive individuals, 15 or 3.81 percent were heterozygous for the variant allele, whereas 2 of 415 normal individuals were heterozygous for the variant allele . When the info of both cohorts were combined, 38 of 795 hypertensive patients and 4 of 632 normal individuals were heterozygous for the variant allele .Lickerman’s experience is certainly that if asked if they are contemplating suicide, most depressed people will answer honestly. He encourages people to ask that query if they suspect someone they know or like is depressed. Remember, major depression can be a treatable disease. 2 – Psychosis. The schizophrenic person hears evil voices that can command self-destruction. The problem is harder to mask and the worldwide incidence of schizophrenia is about 1 percent. The sufferer will probably discuss the voices in his / her head. Again, schizophrenia can be treatable by medicine, but if left untreated, the individual might need to be hospitalized in a secure, locked ward until the voices subside.