The primary study way of measuring adherence was regular counts of the returned study bottles and tablets: 98 percent of the dispensed study bottles were returned, and 97 percent of dispensed study tablets were taken . Factoring in missed visits, all known reasons for nondispensation of study medicine, and nonadherence to dispensed study pills, we calculated that scholarly study medication was in use during 92.1 percent of the total follow-up time. S1 in the Supplementary Appendix).).23). With both TDF , efficacy of significantly less than 30 percent was ruled out in the primary modified intention-to-treat analysis.‘Whilst advancing female age is clearly associated with fertility decline,’ said Dr Choudhary, ‘there continues to be no consensus about advancing paternal age group and fertility outcome. This is an area which is a lot under-researched still. A few studies show an effect on DNA mutations which might explain a higher rate of miscarriage, pregnancy loss and birth defect. Advanced paternal age offers been associated with long-term disorders in offspring also. But the available evidence is limited. ‘Our results suggest that, to the age of 45 up, there is little aftereffect of male age group on treatment end result, but sperm donors are a selected people based on good sperm quality. Our study implies that we are good at choosing the right sperm donors with the proper sperm quality – and that's so why we found no difference in live birth rate despite the increasing age of sperm donors.