By one year, just four % of workers in the counseling group had not returned to work, compared to eight % of those receiving disability evaluation only. The difference mainly resulted from a lower rate of repeated episodes of medical leave among workers assigned to info and guidance: 38 %, compared to 60 % with evaluation just. There was no significant difference in the full total time on sick keep or in the %age of sufferers who eventually underwent medical procedures . Even though low back discomfort is generally a self-limiting condition that improves as time passes, many sufferers have prolonged pain leading to many remedies and prolonged disability. In Belgium, low back pain accounts for one-fourth of all workers on lifetime disability.After the preliminary benefits of the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in holland and the Endovascular Treatment for Little Core and Anterior Circulation Proximal Occlusion with Focus on Minimizing CT to Recanalization Moments trial were reported,16,18 our data and safety monitoring board recommended holding enrollment, and the first interim efficacy analysis was performed slightly early . In 2015 February, the analysis was halted when the interim efficacy analysis showed that the prespecified stopping-criteria boundary for efficacy had been crossed.