Next, the researchers built a structure resembling a tip link the the CDH23 and PCDH15 proteins in the laboratory and how they interact. If the conditions were right, the two proteins themselves wound tight. Together from one end to another in a configuration that mirrored a naturally occurring compound peak The results were surprising, since the scientific consensus was that these proteins did not interact. Like normal tip links, the structure thrived in calcium concentrations that parallel the inner ear the inner ear fluid, while a drastic reduction of the calcium structure. Structure.
Concluded that the mutation reduces the adhesive properties of the two proteins and prevents the formation of the tip link In a second mutation PCDH15 the tip link ,, the scientists suggested that the deafness is not likely caused by the separation of the tip link but by interference with its mechanical properties.
Funding for this study was provided primarily by the NIDCD Other NIH institutes and centers, have contributed to finance the National Institute of General Medical Sciences , the National Institute of Arthritis and Musculoskeletal and Skin Diseases and the National Center for Research Resources ..He told that many proteins next to beta-catenin on Wnt signaling pathway each having may pathway pathway and triggering self-renewal involved. Last he said The Weissman objective cancer stem cells in Labor be a wide range of types of cancer, by more about the proteins going wrong in these cells identify learn. Finally he said, this work could easily that that shutdown the unreasonable active protein. If these goals these targets be are available, combination treatment would work real has chance, Weissman said.. Weissman said that activate the activation of the Wnt signaling pathway is often mutated to several types of cancer.
Although the cancer stem cell was still wearing a certain similarity to macrophages / granulocytes progenitors, they well as stood apart. One difference was a protein designated beta-catenin is present in large amounts in the nuclei of cancer stem cells. This protein is embryonal embryonic cells, where it is keeps you in a dividing state. ‘What is romantic is that you can switched this gene at a mature cell,’Jamieson said. Protein had especially abundant in human, self renewal were resistant to to the chemotherapy drug Gleevec.
Jamieson and her team work with Irving Weissman, the Karel H. And Avice N. Beekjuis a professor to Cancer Biology and Haematology gentlemen from Stanford, University of Toronto and the UCLA took cell by a careful detective work.