All the individuals were examined by fiberoptic nasopharyngoscopy on weekly-basis through the RT course. The response was evaluated centered by CT or MR pictures taken within a month of radiotherapy completion. Following completion of the prepared treatment timetable including adjuvant chemotherapy, CT, or MR images were repeated every three to four months for the 1st 2 yrs, and every four to six months thereafter. Outcomes: This study was exclusive in that the radiation therapy boost technique used for most of the patients in the study was seen as a three-dimensional conformal methods, while other high dose radiation therapy trials used conventional two-dimensional ways.Results of a report of 1032 individuals with early , active RA originally assessed response to treatment after 26 weeks with ADA 40mg almost every other week + MTX versus MTX only. Results show that 44 percent of patients treated with the mixture therapy achieved the target of sustained low disease activity at week 26, versus 24 percent of these treated with MTX alone. Patients reaching the target on ADA+MTX were considered responders and then further randomised to keep or withdraw from treatment with ADA 40mg almost every other week.