With intermittent episodes of paralysis and stiffness.

The mysterious and intermittent character of the neurologic symptoms, which range from unusual eye motions to seizure-like episodes, to partial and/or full body paralysis often outcomes in an extended diagnostic odyssey for parents and children, relating to Matthew Sweney, M.D., an instructor in the U of U Departments of Neurology and Pediatrics and an epilepsy expert at Primary Children’s Medical Center. Families often present again and again to the emergency room, and kids may undergo dozens of tests and invasive procedures, says Sweney, also a study co-author. Often, it really is only after the spells fail to react to antiepileptic medications that the medical diagnosis is considered. Related StoriesCHOP researchers delay symptoms, extend lifespan in animal model of Batten diseaseApoE4-carrying males with Alzheimer's disease vulnerable to mind bleedsPerisylvian polymicrogyria gene foundThe ATP1A3 gene encodes one particular piece of an integral transporter molecule that normally would move sodium and potassium ions across a channel between neurons to modify brain activity.The investigators were in charge of all the elements of the trial, like the design, data collection, analysis, and interpretation. All the authors wrote the manuscript and attest to the analysis and data. The trial was executed under Investigational New Drug application 104,188 with the meals and Drug Administration . The scholarly study was conducted relative to the protocol, available with the full text of this article at NEJM.org. The PROTECT III trial was conducted at 49 trauma centers in the United States.